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1760 - The Sioux Indians, having been pushed out of Minnesota by the Chippewa, first reach the Missouri River.

On their way to the Missouri, the Sioux drove the Omaha Indians from the Big Sioux and James River valleys.

1792 -Joseph Garreau settles with the Ree Indians at Little Bend of the Missouri.

1794 - 1796 - Registre Loisel builds post on Cedar Island, between Pierre and Big Bend.

Sioux arrival at the Missouri ignites a long war with the Arikara for control of the Missouri Valley in central South Dakota.